Jonathan Levine has come on to direct Mandate Pictures’ now untitled cancer comedy which stars James McAvoy and Seth Rogen. Also joining the film is Anna Kendrick, a Golden Globe nominee for her turn in “Up In the Air.”

The project, previously titled “I’m With Cancer,” was to be directed by Nicole Holofcener who dropped out in November. Levine’s credits include “The Wackness” and “All the Boys Love Mandy Lane.”

Principal photography starts next month in Vancouver. Mandate International will commence pre-sales in Berlin in February.